ID: 2246

• Title:
  Advances in irreversible electroporation technology and novel clinical applications
  
  Authors:
  

  Davalos, Rafael - Virginia Tech
  Campelo, Sabrina - Virginia Tech
  Aycock, Kenneth - Virginia Tech
  Salameh, Zaid - Virginia Tech
  Veronica Ringel-Scaia, Veronica - Virginia Tech
  Alinezhad, Nastaran - Virginia Tech
  Allen, Coy - Virginia Tech

  
  
  Abstract:
  Irreversible Electroporation (IRE) is a minimally invasive surgical therapy we invented to treat unresectable tumors using low-energy microsecond pulses. IRE is unique among tissue ablation techniques in affecting only the cell membrane while tissue molecules, everything encompassing collagen structures to proteins; remain intact, thereby making treatment near critical structures such as major blood vessels and nerves possible. We are developing an advanced form of the technology, high frequency irreversible electroporation (HFIRE) for the treatment of cancer. This new therapy preferentially targets cancer cells over healthy cells, promotes a positive immune response, and alleviates the need for a paralytic. Our preclinical work focuses on helping canine patients with spontaneous disease, which are excellent translational models for human disease. Results of our ongoing trials have been extremely positive, supporting that HFIRE is effective for the treatment of cancer, including tumors refractory to surgery, radio- and chemotherapies.
  
  Keywords:
  Irreversible Electroporation, Pulsed Field Ablation, Non-thermal Ablation
  
  Refs:
  
  
  Topic 1:
  6. Cancer treatment and tumor ablation
  
  Topic 2:
  12. Biomedical applications