ID: 2241

• Title:
  Underwater shock wave driven vaccine/drug delivery
  
  Authors:
  

  Hosseini, Seyedmasih - Graduate School of Science and Technology, Kumamoto University, Japan
  Hosano, Nushin - Biomaterials and Bioelectrics Department, Institute of Industrial Nanomaterials, Kumamoto University, Japan
  Menezes, Viren - Department of Aerospace Engineering, Indian Institute of Technology Bombay, Powai, Mumbai, India 
  Hosano, Nushin - Biomaterials and Bioelectrics Department, Institute of Industrial Nanomaterials, Kumamoto University, Japan

  
  
  Abstract:
  The concept of needle-free vaccine/drug delivery has been an interesting non-invasive substitute for hypodermic needle injection. The development of this type of delivery intends to avoid problems associated with needles such as pain and phobia, contaminated waste, and disease expansion, while simultaneously improving the limitations of previous injectors. The earlier developments were unable to inject small volumes and were only able to deliver into the deeper layers of the skin. A relatively new take on this challenge is through shock wave-driven jet injectors. By delivering pulse liquid jets at a high speed, such devices are able to enhance the previously attempted developments in such a way that is both efficient and cost-effective. A device able to provide such delivery is a micro-jet injector consisting of a shock wave generator and a drug holder. The device also contains a converging micro-nozzle. During the injection, incident shock waves compress the drug in the drug cavity, of which the quick deformation directs drug into the micro-nozzle. A mixture of gelatin and water models are used to test the penetrability of the device. An ultra-high-speed camera with laser light source is used to analyze the structure and the speed of the injection. Theoretical and mechanical analysis are carried out on the mechanism of delivery, the power of the shock wave impulse, and the speed of the jet to predict the results, and to make sure the development is practical, profitable, and time-saving.
  
  Keywords:
  Underwater shock wave; Vaccine/drug delivery; Non-invasive; Optimization
  
  Refs:
  
  
  Topic 1:
  12. Biomedical applications
  
  Topic 2:
  4. Diagnostics, analytics, experimental techniques