ID: 2240

• Title:
  Theranostics by microstreaming of shock waves
  
  Authors:
  

  Hosano, Nushin - Biomaterials and Bioelectrics Department, Institute of Industrial Nanomaterials, Kumamoto University, Japan
  Hosano, Hamid - Biomaterials and Bioelectrics Department, Institute of Industrial Nanomaterials, Kumamoto University, Japan

  
  
  Abstract:
  Among different biological, chemical, or physical stimuli for cell manipulation, physical stresses are of particular interest, as they can transiently increase the permeability of the cell membrane with less side effects. Recent progress in nanosecond duration ultra-high voltage pulses provides exciting possibilities to produce direct intracellular effects. Meanwhile, we have been using ultrashort pulses and miniature shock drivers to generate fine micro underwater shock waves, which can penetrate deep in soft tissue. These unique characteristics make them appropriate for delivering energy for vaccine/drug delivery. Ultrasound and shock wave can be applied through totally non-invasive procedures taking advantage of focusing in soft tissue, appropriate for clinical therapy. We utilized micro-streaming of shock wave and cavitation to deliver liquid vaccine/drug to the depth of dermis. The paper will cover our experiences with shock waves and pulse ultrasound for minimally invasive pain-free needleless microfluidic vaccine/drug delivery.
  
  Keywords:
  Non-invasive drug delivery, Shock Waves, Microfluidics
  
  Refs:
  
  
  Topic 1:
  4. Diagnostics, analytics, experimental techniques
  
  Topic 2:
  12. Biomedical applications